To overcome the challenge of increasing food production with a significant reduction of agrochemicals use and environmental pollution (especially from synthetic chemicals), a great deal of interest and research have been devoted to beneficial microbes (BM) in recent days. Years of experiments in controlled environments suggest that the potential upside in production will be real, i.e., crops inoculated with BM biostimulants will outperform non-inoculated ones. There are numerous examples of positive effects on plant growth and fruit quality enhancement as well as disease resistance by BM. Growth enhancement in horticultural crops such as tomatoes and strawberries has been achieved by applying these BM early in the seedling production stage. The enhanced growth and root system colonization by BM also provided protection from soil-borne disease organisms. However, application method and timing can determine the outcome from such treatments. Application methods and results from some recent studies on tomatoes, eggplants, okras and strawberries will be presented.